Identification of a New Virulence Factor, BvfA, in Brucella suis
نویسندگان
چکیده
منابع مشابه
Identification of a new virulence factor, BvfA, in Brucella suis.
We report the identification of BvfA (for Brucella virulence factor A), a small periplasmic protein unique to the genus Brucella, which is essential for the virulence of Brucella suis. A BvfA knockout mutant was highly attenuated both in in vitro macrophage infection assays and in vivo in the murine model of brucellosis. Fluorescence-activated cell sorting analysis with green fluorescent protei...
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متن کاملDetection of virulence genes (bvfA, virB and ure) in Brucella melitensis isolated from aborted fetuses of sheep and goats
BACKGROUND AND OBJECTIVES Brucella, causative of brucellosis, has some potential virulence factors involved in Brucella replication and its strategies to circumvent the immune response. One of them is the virB gene that encodes the type IV secretion system proteins (T4SS) involved in intracellular replication of organism. Brucella virulence factor A (bvfA), and urease (ure) has also been descri...
متن کاملThe TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence.
Brucella spp., like other pathogens, must cope with the environment of diverse host niches during the infection process. In doing this, pathogens evolved different type of transport systems to help them survive and disseminate within the host. Members of the TolC family have been shown to be involved in the export of chemically diverse molecules ranging from large protein toxins to small toxic ...
متن کاملdetection of virulence genes (bvfa, virb and ure) in brucella melitensis isolated from aborted fetuses of sheep and goats.
background and objectives: brucella, causative of brucellosis, has some potential virulence factors involved in brucella replication and its strategies to circumvent the immune response. one of them is the virb gene that encodes the type іv secretion system proteins (t4ss) involved in intracellular replication of organism. brucella virulence factor a ( bvf a), and urease ( ure ) has also been d...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.9.5524-5529.2005